Fri Feb 13 2026

211 articles - From Friday Feb 06 2026 to Friday Feb 13 2026

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol
Artificial Intelligence for Gastroenterology Practice: A Modified Delphi Consensus.

This consensus outlines how AI can augment rather than replace clinical expertise while promoting safety, transparency, interoperability, and equity. Priorities include pragmatic and prospective trials, multi-institutional data-sharing consortia, bias mitigation, and workforce training to enable trustworthy and clinically impactful AI adoption in GI, liver, and endoscopy care.

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Gastroenterology
Establishing Adenoma Testing Guidelines for Diagnosing Mosaicism.

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Gastrointest Endosc
Enhancing gastroenterology education through e-learning.

This article explores the transformative impact of e-learning on gastroenterology education, highlighting the advancements and benefits brought by the American Society for Gastrointestinal Endoscopy (ASGE) platforms. ASGE's e-learning platforms offer specialized content, interactive tools, and continuous updates, enhancing the learning experience for gastroenterologists.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther
Network Meta-Analysis: Comparison of Pharmacological Therapies in Compensated Metabolic Dysfunction-Associated Steatohepatitis Cirrhosis for Fibrosis Regression and MASH Resolution.

This network meta-analysis provides relative rank-order estimates of the histological efficacy of available pharmacological therapies for compensated MASH cirrhosis. These data may have implications for the design of future clinical trials.

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Am J Gastroenterol
Antibiotic Use Linked to Worse Outcomes in Gastrointestinal and Liver Cancer Patients on Immune Checkpoint Inhibitors: A Meta-Analysis.

Antibiotic use is associated with worse outcomes in gastrointestinal or liver cancer patients receiving ICIs and should be carefully justified. Prospective studies are needed to validate these results.

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Gastrointest Endosc
Efficacy of Artificial Intelligence-Assisted Upper Gastrointestinal Endoscopy for Neoplasm Detection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

AI-EGD demonstrated superior performance compared to Co-EGD in detecting UGI neoplasms, particularly for lesions measuring 10 mm or more less. The higher detection rate of LGIN highlights the potential clinical value of AI support. Further trials are warranted to assess the impact of AI across varying levels of endoscopist experience.

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Hepatology
Impact of newer antihyperglycemic agents on hepatic complications: A systematic review and meta-analysis of data from 5.3 million patients with type 2 diabetes mellitus.

GLP-1 RAs and SGLT-2 inhibitors were associated with hepatoprotective effects compared with other glucose-lowering therapies in patients with T2DM, with GLP-1 RAs showing additional benefits in chronic liver disease. These findings provide evidence on the relationships between antidiabetic drug classes and liver-related outcomes in patients with T2DM and may inform clinical decision-making.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Liver Steatosis-Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication.

PRS-5 is independently associated with increased HCC risk after HCV eradication, supporting its role in personalised HCC surveillance strategies.

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Safety of Immune Checkpoint Inhibitors Prior to Liver Transplantation in Hepatocellular Carcinoma.

Our results demonstrate that rejection rates were similar in patients receiving ICIs pre-LT and it can be safely managed.

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Am J Gastroenterol
Autonomic Dysfunction in Gastroduodenal Disorders Evaluated through Multimodal Non-Invasive Physiological Testing.

Autonomic dysfunction independently predicted delayed gastric emptying and revealed a gastroparesis mechanism distinct from gastric myoelectrical impairment. Autonomic dysfunction altered the postprandial gastric motor response and was associated with a greater symptom burden. Multimodal physiological testing including autonomic profiling reveals distinct mechanistic subgroups in patients with chronic gastroduodenal symptoms.

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Biomarker Use in Barrett's Esophagus Surveillance.

As such, many studies to develop validated biomarkers that either assist in dysplasia assessment or independently serve as predictors of progression risk have been performed. In this review, we will summarize some of these studies, primarily focused on p53, abnormal genomic content, and methylated DNA markers, which have shown promise for their ability to identify patients at increased risk of progressing to more advanced disease.

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Colon-Pilot: A Generative AI Tool for Automated Colonoscopy Surveillance Recommendations and 2024 ACG/ASGE Quality Benchmarking.

Colon-Pilot demonstrated high fidelity in applying surveillance guidelines and automated quality benchmarking, outperforming unassisted endoscopists in guideline adherence. By combining safety protocols with large-scale automated reporting, it offers a scalable solution for improving both efficiency and quality in colorectal cancer prevention.

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Computer-Aided Colonoscopy Alert Fatigue and Its Effect on Adenoma Detection.

CADe assistance significantly improved ADR during early-day colonoscopies, but this benefit disappeared in later-day procedures. This pattern suggests that alert fatigue may limit endoscopists' responsiveness to CADe prompts as the day progresses.

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ELECTRONIC HEALTH RECORD CLINICAL DECISION SUPPORT TOOL IMPROVES AMBULATORY REFLUX TESTING PRACTICES.

Use of CDS for reflux testing improves ordering practices and meaningful changes clinical management.

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Infliximab and Upadacitinib Demonstrate Superior Early Onset of Efficacy in Biologic-Naïve Ulcerative Colitis with Severe Endoscopic Disease.

Among biologic-naïve UC patients with severe endoscopic disease, infliximab and upadacitinib had the highest rates of week 2 and post-induction PRO-2 response. Baseline disease activity may help to better inform treatment choices.

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Nociplastic Pain is Associated with Increased Healthcare Utilization and Lower Quality of Life in Patients with Inflammatory Bowel Disease.

NP is common in IBD and linked to psychosocial comorbidity, higher healthcare use, and reduced QoL.

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Normalization of Dyssynergic Bear Down Patterns in the Seated Position Predicts Normal Balloon Expulsion Testing on High-Resolution Anorectal Manometry.

Testing in the seated position may more reasonably predict BET success. A seated assessment may enhance diagnostic accuracy in defecation disorders.

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Outcomes of Artificial Intelligence Enhanced Colonoscopy in a Tertiary Clinical Setting.

Implementing CADe in clinical practice significantly improved ADR, PDR, APC, and PPC. However, the increase in ADR appears inflated by the detection of polyps ≤ 5 mm, whose clinical significance in reducing CRC remains uncertain.

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Prior Abdominal Surgery is Not Associated with Adverse Pregnancy, Delivery or Neonatal Outcomes in Women with Crohn's Disease: Results from the Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) Study.

Prior surgery was not associated with adverse pregnancy or neonatal outcomes in CD.

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Proton Pump Inhibitors are More Cost-Effective than Potassium Competitive Acid Blockers for Gastroesophageal Reflux Disease.

Despite PCAB efficacy, PPIs are a cost-effective strategy for GERD treatment, and can be positioned ahead of PCAB escalation on this basis. Reducing PCAB costs or accepting a higher WTP threshold would influence this finding, though PCABs may be favored in some current situations as evidenced by probabilistic sensitivity results.

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Risk Factors for Proximal and Distal Advanced Colorectal Conventional and Serrated Neoplasia in Adults Under Fifty Years of Age.

We identified modifiable risk factors including current smoking and higher BMI in young adults with right and left sided colorectal polyps. Older age, male sex and family history were non-modifiable predictors. These data can help to inform screening and prevention of CRC in young adults.

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Vonoprazan Is Associated with Better Liver-Related Outcomes Compared to Proton Pump Inhibitors In Cirrhosis.

Adjusted analysis showed lower 6/12-month outcomes with vonoprazan versus PPI for mortality (aHR-0.36/0.39), infections (aHR-0.60/0.67), liver-complications (aHR-0.16/0.18), and liver-related hospitalizations (aHR-0.12/0.13), which remained largely consistent on sensitivity analyses. Cirrhosis patients on PCABs demonstrate lower risk for poor outcomes at 6 and 12-months versus PPIs.

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Clin Gastroenterol Hepatol
Alkaline Phosphatase Normalization Occurs Less Frequently in Hispanic Patients with Primary Biliary Cholangitis.

Hispanic patients with PBC, and more broadly non-White patients, were significantly less likely than NHW patients to achieve CBR despite comparable baseline ALP levels. As ALP normalization becomes the preferred therapeutic target, addressing barriers to treatment response in underserved populations is essential.

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Association of change in healthy lifestyle in early adulthood with steatotic liver disease risk in midlife.

Maintaining or improving healthy behaviors during early adulthood was associated with a reduction of midlife SLD risk, regardless of genetic predisposition.

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Clinical utility and diagnostic accuracy of the GAAD score in non-cirrhotic patients with focal liver lesions.

In this cohort of non-cirrhotic patients with focal liver lesions, the GAAD score was highly predictive of HCC and offered superior diagnostic accuracy over AFP and PIVKA-II alone. These findings support the use of the GAAD score to guide management decisions in these patients.

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Clinical utility of a 50% and 30% decline in MRI-PDFF in predicting fibrosis improvement in metabolic dysfunction-associated steatohepatitis.

MRI-PDFF super-response predicts fibrosis regression without worsening MASH, and a greater likelihood of MASH resolution without worsening fibrosis than MRI-PDFF response.

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Diagnostic Accuracy of Non-Invasive Tests for MASLD Across Age, Type 2 Diabetes, and Obesity Subgroups: A Multinational Study.

Accuracy of non-invasive tests for advanced fibrosis in MASLD is influenced by age, T2D, and obesity. Age-adjusted FIB-4 thresholds may enhance risk stratification. Imaging-based and composite NITs (LSM and Agile-3+) provide more consistent performance across MASLD subpopulations.

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Early treatment initiation optimizes virologic and liver outcomes in pediatric patients with chronic hepatitis B aged 0-18 years.

Initiating treatment at a younger age predicts more positive and rapid HBV clearance in children with CHB. Early intervention also improves hepatic elastography parameters in children with CHB.

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Feasibility and diagnostic accuracy of a capsule-sponge device for esophageal squamous neoplasia (EDEN trial).

In this case-enriched cohort, the capsule-sponge was safe and feasible, and cytology with adjunct p53-IHC showed high accuracy for ESN/early ESCC. Validation in asymptomatic high-risk cohorts is warranted to define real-world performance and triage utility (NCT04192695).

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Gaze shift to screen edge boosts colorectal adenoma detection: multicenter randomized controlled trial (EYE-SIGHT trial).

Increased peripheral gaze by real-time guidance significantly improved adenoma and polyp detection without extending procedure time. This low-burden, scalable approach may offer a simple, effective method to improve colonoscopy. UMIN-CTR, UMIN000055006,

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Impact of Narrow-Band Imaging on Sessile Serrated Lesion Miss Rate: A Multicenter Randomized Tandem Colonoscopy Trial.

NBI significantly reduces the miss rates of SSLs, proximal serrated lesions, and adenomas without reducing that of advanced SSLs. (NCT05684328).

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ONE-YEAR CHANGES IN LSM, BUT NOT IN ALT AND CAP, PREDICT LONG-TERM LIVER OUTCOMES IN PATIENTS WITH MASLD.

In MASLD patients with LSM ≥8 or ≥10 kPa, the % LSM reduction at 1 year was independently associated with lower risk of LRE and LD.

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Peginterferon α-2b Enhances HBsAg Loss in NA-Suppressed Low-HBsAg Chronic Hepatitis B Patients: Everest Study in China.

PegIFNα-2b enhances HBsAg loss in NA-suppressed, HBeAg-negative CHB patients with low HBsAg levels. Baseline and on-treatment predictors support the achievement of a functional cure.

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Peppermint oil and sweets in pediatric irritable bowel syndrome and functional abdominal pain: a randomized trial.

Neither peppermint oil nor peppermint sweets were superior to placebo in treating paediatric IBS and FAP-NOS. These findings suggest prioritizing proven gut-brain axis-targeted interventions for this population.

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Prediction of inflammatory bowel disease based on early life risk factors in a population-based cohort.

In a nationwide cohort with long-term follow up data, early life exposures were predictive of UC, especially younger-onset disease, while prediction of CD was less accurate.

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Progression of Liver Fibrosis and Liver-Related Event Risk in MASLD at High Cardiovascular Risk.

Higher cardiovascular risk is associated with greater prevalence of advanced liver fibrosis , liver stiffness progression, and LRE incidence in MASLD.

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Revisiting the obesity paradox in MASLD: longitudinal trajectory analysis reveals time-varying mortality risks.

This study demonstrates that the association between obesity and MASLD outcomes is heterogeneous and depends on the timing of obesity exposure. Long-term BMI trajectory analysis suggests that obesity does not confer a survival advantage in MASLD, whereas maintaining non-obese status throughout adulthood is associated with lower overall mortality.

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Risk stratification of a novel non-invasive fibrosis score in metabolic dysfunction-associated steatotic liver disease.

MFS optimally stratifies MASLD patients with high risk for developing long-term liver-related events and mortality.

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Tailored treatment of functional dyspepsia with nortriptyline: a multi-center, double-blind, placebo-controlled trial.

Nortriptyline was not more effective than placebo in reducing FD symptoms in participants pre-selected based on CYP2D6 genotype, although a biological effect of nortriptyline could not be ruled out. However, effects related to participants' belief appeared to be stronger; number, NCT03652571.

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Ustekinumab and JAK inhibitors outperform vedolizumab as second-line therapy in anti-TNF-experienced patients with ulcerative colitis.

Ustekinumab and JAKi were more effective than vedolizumab in inducing steroid-free and biochemical remission following anti-TNFα failure. Safety concerns with JAKi warrant careful patient selection in clinical practice.

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Validation of THCC-RI in the Hepatocellular Carcinoma Early Detection Strategy (HEDS) Study.

In an independent multi-center cohort, THCC-RI had good performance for predicting the future risk of HCC in patients with cirrhosis, with stable discrimination and calibration over a 5-year follow-up. Implementation of THCC-RI into clinical care pathways requires further research.

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Endoscopy
Survival In Post-Endoscopy Esophageal Cancer: A Nordic Population-Based Cohort Study.

The 5-year survival in patients with PEEC seems to be better than in those with other esophageal cancer, but the survival is still poor.

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Gastroenterology
Genetic Risk of Inflammatory Bowel Disease Is Associated With Disease Course Severity.

Patients with higher genetic burden for developing IBD also experience a more severe disease course. For patients with CD this link was largely mediated by disease extent, however, this was not the case for UC, which suggests a shared genetic architecture between disease susceptibility and severity.

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Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.

Ancestry-informed regression enabled identification of novel AFR and AIAN-specific risk alleles, which may also inform observed phenotypic differences. We have shown that some previously identified IBD loci have associations that are EUR-specific. These findings highlight the importance of genetic ancestry for elucidating the biological underpinnings of IBD and may have important pharmacogenetic implications.

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Multicenter Prospective Cohort Study on Clinical Outcomes and Fibrosis Patterns in Biopsy-Proven Steatotic Liver Disease Subtypes.

MetALD and ALD are independently associated with substantially increased all-cause mortality and LRE risks compared with non-SLD. Distinct zone-specific collagen patterns identified by AI analysis suggest unique fibrotic progression pathways in MetALD and ALD, supporting the need for tailored risk stratification and targeted management strategies.

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TEM OR ESD IN EARLY RECTAL TUMORS: A CLINICAL & COST-EFFECTIVENESS ANALYSIS.

For ERT, ESD was more cost-effective and offered higher-quality excision and lower recurrence rates than TEM. (ClinicalTrials.gov NCT02885142).

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Vonoprazan-tetracycline dual regimen as rescue therapy for Helicobacter pylori infection: randomized controlled trial.

Fourteen-day vonoprazan-tetracycline dual therapy is an effective and well-tolerated rescue regimen for Helicobacter pylori infection. This simplified regimen achieved eradication rates non-inferior to BQT while substantially reducing adverse events and improving adherence. (chictr.org.cn, ChiCTR2400080705).

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Gastrointest Endosc
Amber-red color imaging for enhanced anatomical structures recognition in third-space endoscopy: a prospective video-based study.

ACI enhances recognition of submucosal vessels, submucosal and muscle layers in ESD and POEM, benefiting both experts and non-experts, and may serve as a valuable adjunct in third-space endoscopy.

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Comparison of Anti-Migration versus Conventional Fully Covered Self-Expandable Metal Stents for Malignant Distal Biliary Obstruction: A Single-Center Long-Term Study.

Anti-migration FCSEMSs demonstrated lower crude migration with similar patency (RBO risk), but adjusted analyses did not reach statistical significance.

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Evaluating Clinical Outcomes and Adverse Events: Risk Stratification of EUS-Guided Through-the-Needle Biopsy for Pancreatic Cyst in a Large Cohort.

EUS-TTNB demonstrated notable clinical utility in revising diagnoses and influencing therapeutic decisions but poses a considerable risk of AEs. By applying this risk categorization model with careful consideration and patient selection, its clinical utility may be enhanced.

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Long-term outcome after endoscopic resection for esophageal squamous cell carcinoma invading muscularis mucosa without lymphovascular invasion: a multicenter retrospective study.

Although CRR was not negligible; however, the current strategy of observation may be a reasonable option given the low recurrence risk.

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Long-term outcome after endoscopic submucosal dissection for entire circumferential cT1aN0M0 esophageal squamous cell carcinoma.

The long-term outcomes of each treatment group for entire circumferential cT1aN0M0 ESCC were elucidated. The esophageal stricture and refractory stricture rates after ESD were higher than those in other patients. Further investigations in large cohorts are necessary to clarify the indication criteria for ESD in patients with lesions.

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The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial.

The addition of diluted epinephrine to the injection solution significantly reduces the procedure time for gastric ESD. (ClinicalTrials.gov NCT04032119).

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Gut
<i>Acinetobacter baumannii</i> promotes gastric cancer metastasis via NA-mediated NAD metabolism reprogramming and glycolytic activation.

While in enhancing NAD metabolism in GC cells through NA synthesis, consequently promoting GC metastasis. These findings establish a microbiota-metabolism axis as a mechanistic foundation for developing targeted therapeutic strategies against GC metastasis.

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Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer.

Overall, our work has uncovered the diverse gene features and varied anti-HBV activities of plasmablast-derived mAbs, providing a series of antibody drug candidates and the long-sought-after atomic model of AGL has paved the way for a wholistic characterisation of the AGL's dynamic conformation during HBV infection and immune response.

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Effect of long-term adherence on faecal immunochemical test positivity rate, positive predictive value and detection rate in organised population-based colorectal cancer screening.

After an initial round with the highest FIT-positivity and detection rates, screening outcomes stabilise at lower levels reflecting neoplasia removal and subsequent selection of a lower-risk population. Because detection rates remain clinically relevant even in an adherent cohort, early screening cessation after a sequence of normal biennial FITs is not justified.

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Endothelial RAP1A attenuates sinusoidal capillarisation and liver fibrosis by inhibiting RAF1-mediated Notch activation.

Objective This study aimed to investigate the role of the endothelial GTPase RAP1A in sinusoidal capillarisation and liver fibrosis. Design Liver fibrosis models were induced by HFHCD, CDAHFD, CCl is essential for maintaining LSEC homeostasis and represents a potential intervention target for liver fibrosis.

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Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer.

This proteogenomic framework defines exposure-informed and microbiome-informed gastric cancer subtypes, providing a molecular schema for patient stratification, prevention and actionable therapeutic vulnerabilities.

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KRAS-driven protein disulfide isomerase family A member 6 expression suppresses PRKR-like endoplasmic reticulum kinase-mediated immunogenic cell death to desensitise pancreatic ductal adenocarcinoma to immune checkpoint blockers.

PDIA6, driven by KRAS G12D , alleviates ICD and promotes immune evasion, functioning as a predictive biomarker to screen ICB-sensitive patients and a therapeutic target to improve ICB efficacy in PDAC with KRAS mutations.

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Kynurenic acid mitigates poststroke brain damage through the gut-brain neural circuit.

KYNA acts through an intestinal GPR35-vagus neural pathway to influence stroke recovery, highlighting this gut-brain signalling axis as a promising therapeutic avenue.

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Low-frequency repetitive transcranial magnetic stimulation attenuates visceral pain in IBS with diarrhoea via inhibition of the medial prefrontal cortex.

Hyperexcitability of the mPFC drives chronic visceral pain in patients with IBS-D and lf-rTMS provides analgesia by suppressing this hyperactivity, offering a novel, mechanism-based neuromodulation strategy for IBS-D treatment.

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MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming.

Our data demonstrate that the enhanced MTFP1 expression leads to an upregulated glutamine-OXPHOS axis in PDAC liver colonisation. This metabolic shift is triggered by the ROS/PI3K/AKT/c-MYC/SLC1A5 pathway. Targeting MTFP1 may be a potential therapeutic strategy for PDAC patients with liver metastasis.

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Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study.

PI-DGBI represents a significant subset of DGBI, with distinct sociodemographic and clinical characteristics. These findings highlight the role of acute gastroenteritis in triggering the onset of long-term gastrointestinal disorders and underscore the need for targeted interventions to mitigate its impact on patient health.

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Prospective evaluation of radical surgery for adenocarcinoma of oesophagogastric junction: real-world insights from the CLAEG study.

The CLAEG study shows that abdominal lymphadenectomy should be prioritised in AEG, with neoadjuvant therapy, total gastrectomy and laparoscopy associated with favourable short-term outcomes.

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SDC1<sup>+</sup> CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers.

Our study establishes SDC1 + CAFs as a universal, metastasis-promoting CAF subset across multiple cancer types and uncovers a novel KLF6-CTGF-FGFR3 axis that drives EMT and tumour dissemination. These findings provide mechanistic insight into CAF-tumour cell crosstalk and highlight actionable stromal targets for anti-metastatic therapies across diverse malignancies.

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Trogocytosis-orchestrated CLDN18.2-"dressed" CD8<sup>+</sup> T cells drive pancreatic cancer progression via glucose metabolic reprogramming-induced cytotoxicity debilitation and systematic immune senescence cascade.

Trogocytosis-related CLDN18.2 inhibited the glucose uptake, glycolysis and cytotoxicity of tumour-infiltrating CD8 + T cells by promoting the ubiquitin-proteasomal degradation of β-catenin in PDAC. Therefore, targeting trogocytosis-related CLDN18.2 + CD8 + T cells may be a promising therapeutic strategy to inhibit PDAC progression.

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Hepatology
Age and sex influence transcriptomic responses to statin therapy that control liver aging during systemic metabolic dysfunction.

Age-dependent transcriptional remodeling in the liver differs in statin users and non-users. Pathways involved in senescence are suppressed while those that promote ferroptosis are induced in statin users. These results suggest that statins may suppress biological aging in MASLD by acting as senolytics and highlight the complex, context-specific roles of senescence in liver adaptation and remodeling.

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Association between statin use and hepatic decompensation in patients with primary biliary cholangitis: A target trial emulation study.

Statin use was consistently associated with a lower risk of hepatic decompensation and major liver events in patients with PBC, supporting a potential protective effect.

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CDK8 and CDK19 Mediator kinases are required for hepatitis delta virus replication.

Our findings reveal the essential role of CDK8/19 in mediating the transcriptional activity of Pol-II during HDV replication, which is partially counteracted by HDV-encoded small HDAg.

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Hepatic GPR75 exacerbates MASH through GNAI2-Dependent signaling.

This study demonstrates that GPR75 serves as a novel regulator of MASLD /MASH by modulating hepatic fatty acid metabolism. These findings suggest that GPR75 suppression may represent a potential therapeutic strategy for MASLD/MASH treatment.

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Incorporating artificial intelligence into imaging for surveillance and diagnosis of liver cancer: Innovations, challenges, and clinical translation.

Large, prospective multicenter validation studies are essential to confirm clinical benefit and safety. Ultimately, the careful implementation of trustworthy and explainable AI tools could enable earlier detection, greater diagnostic precision, and more equitable liver cancer care.

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Lipid nanoparticle-delivered ornithine transcarbamylase mRNA alleviates liver fibrosis in preclinical models.

Collectively, our study provides the first direct preclinical evidence supporting OTC mRNA therapeutics for treating liver fibrosis and establishes proof-of-concept for mRNA therapy as a novel strategy to reverse liver fibrosis.

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Statins halt polycystic liver disease by reprogramming metabolism and normalizing mitochondrial bioenergetics in cystic cholangiocytes.

Mitochondrial and metabolic dysregulation are central to the pathogenesis of PLD. Targeting cholesterol metabolism with statins represents a promising therapeutic strategy to slow disease progression and reduce cyst burden.

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Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses.

Our large-scale GWAS highlights new genetic variants and HLA-linked mechanisms underlying CCA susceptibility. Integrating multi-step post-GWAS approaches enhances understanding of CCA pathogenesis and may facilitate the development of risk biomarkers for early detection and precision prevention strategies.

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Understanding hepatopancreatobiliary cancer risks in a population-based primary sclerosing cholangitis-inflammatory bowel disease cohort.

While some individuals with PSC-IBD experience an extended event-free disease course, a large proportion experienced disease-related cancer, colectomy, cholecystectomy and transplant events. Higher mortality rates observed after surgery are likely related to underlying disease processes that motivated surgical intervention (e.g. dysplasia/malignancy, refractory IBD), rather than the surgery itself. Understanding how PSC-IBD disease trajectories vary can inform individual management and patient counselling.

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J Hepatol
Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD.

Both diets ameliorated MASLD, but KD produced a greater reduction in IHTG owing to a starvation-like metabolic state. However, the benefits of KD were accompanied by increased hepatic mitochondrial redox state and suppression of TCA cycle oxidation, which are features previously linked to progressive liver injury. Impact and implications This study provides mechanistic justification for considering dietary composition, in addition to caloric restriction, as a key determinant of steatosis resolution in MASLD. The findings highlight a potential trade-off between greater short-term reductions in liver fat and the emergence of metabolic features previously associated with increased susceptibility to liver injury. While a ketogenic diet may facilitate rapid liver fat reduction in selected clinical contexts, its use should be approached cautiously, particularly in individuals with advanced MASLD. These results underscore the need for systematic evaluation of dietary composition as a determinant of both efficacy and safety of nutritional interventions for MASLD. Clinical trial number NCT03737071.

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IL22 supports Long-Term Expansion of Mouse and Human Hepatocytes.

IL22 enables large-scale expansion of both mouse and human hepatocytes in vitro by activating the Stat3-Bhlha15/Arntl2 axis. Our discoveries may support future utilization of IL22 in liver/hepatocyte-related clinical applications. Impact and implications Hepatocytes have wide applications in drug development, disease modeling, and cell therapy. However, expanding hepatocytes in large quantities in vitro without compromising their functions remains a significant challenge. We demonstrate that IL22, a unique cytokine primarily mediating localized epithelial repair and cytoprotection without inducing systemic immune activation, enables large-scale expansion of both mice and human hepatocytes in vitro by activating the Stat3-Bhlha15/Arntl2 axis. Our findings not only bridge the gap between liver regeneration in vivo and hepatocyte growth in vitro, but also support the future utilization of IL22 in liver/hepatocyte-related clinical applications.

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Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.

Intestinal cathepsin B is an essential mediator of gut barrier dysfunction and therapeutic target in alcohol-associated liver disease. Impact and implications Intestinal barrier disruption facilitates the microbial translocation to the liver, contributing to the progression of alcohol-associated hepatitis, however the molecular mechanisms driving barrier dysfunction remain incompletely understood. Our study identified the protease cathepsin B as a key contributor to the progression of alcohol-associated liver disease by degrading the extracellular region of tight junction protein occludin in the intestine, which in turn leads to barrier disruption. This work advances the field by addressing causality, uncovering the molecular target, and proposing cathepsin B as a promising therapeutic target in alcohol-associated hepatitis, a condition for which liver transplantation remains the only effective treatment in a limited subset of patients.

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Serum procalcitonin: A novel tumor biomarker for diagnosis and disease monitoring in fibrolamellar hepatocellular carcinoma.

Procalcitonin is a sensitive and specific serum biomarker for FLC among primary liver cancers, with potential utility in diagnosis and monitoring of treatment response. Impact and implications This study is justified by the lack of reliable serum biomarkers for fibrolamellar carcinoma and demonstrates that procalcitonin is specifically overexpressed by FLC tumor cells and detectable in the blood of the patients with FLC. These findings are important for clinicians and researchers, as they identify a readily available biomarker that may facilitate diagnosis, improve disease monitoring, and support clinical trial design in a rare cancer that predominantly affects young patients. In clinical practice, serum PCT measurement could be incorporated as a non-invasive adjunct to imaging for the diagnosis and longitudinal assessment of FLC, although prospective studies in larger and more diverse cohorts are needed to refine diagnostic cut-offs and confirm specificity.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial: Beyond Viral Eradication-Cardiometabolic Risk and Cardiovascular Outcomes After SVR in Chronic Hepatitis C.

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Editorial: Does Antibiotic Prophylaxis of Spontaneous Bacterial Peritonitis Improve Outcomes in Decompensated Cirrhosis? Insights From a National Cohort.

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Review Article: Renal Safety Profiles of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, and Entecavir for the Treatment of Chronic Hepatitis B Infection-General and Special Populations.

Current first-line NUCs show comparable renal safety profiles in CHB patients with no or mild kidney dysfunction, with growing evidence that favours TAF. Future prospective studies are needed to validate these findings, and more research should focus on CHB patients with diabetes mellitus who are at risk of CKD.

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Clin Gastroenterol Hepatol
Cost-effectiveness Models for Celiac Disease Mass Screening are Encouraging, but Policy Makers Need More.

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New Lessons in DILI: Rising Hepatotoxicity of Oncologic Agents and Predicting Very Short-term Survival in DILI Liver Failure.

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Time for zero tolerance of low Cecal Intubation Rates.

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Gastroenterology
Interventional Endoscopic Ultrasound.

These advances offer safer less invasive alternatives to traditional therapies and define disruptive technologies that are impacting patient care. The purpose of this manuscript is to discuss the state-of-the-art in therapeutic EUS procedures focusing on current advances that are transforming endoscopic patient care.

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Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease.

Monitoring mode-of-action-specific pharmacodynamic modules in the context of disease-related resolution pathways will guide assessment of novel and existing therapies. Artificial intelligence-assisted tools will be key to enabling this development, improving reproducibility, limiting costs, and delivering fast detection.

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Gastrointest Endosc
TOPICAL HEMOSTATIC THERAPIES FOR ENDOSCOPIC TREATMENT OF NONVARICEAL GASTROINTESTINAL BLEEDING.

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Gut
CPS1: a multipurpose mitochondrial enzyme, bile protein, acute liver injury biomarker, and cytokine.

CPS1 also plays a growing role in several cancers, by CPS1 upregulation or downregulation, particularly via metabolic reprogramming which alters the tumour microenvironment and impacts cancer growth and progression. Therefore, CPS1 has multiple enzymatic and non-enzymatic touch points spanning a wide range of cellular and extracellular functions and roles, with important physiological, homoeostatic, genetic disease, diagnostic and potential therapeutic clinical implications.

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Modulating the gut-reproductive tract axis: microbial influence on gynaecological cancer pathogenesis and treatment.

However, most of these applications remain investigational, and current evidence is limited by heterogeneity across study designs, patient cohorts and cancer subtypes. This review summarises current understanding of gut microbiota profiles in reproductive tract cancers, examines potential mechanisms by which the microbiota influences malignancy, discusses its impact on therapy response and explores its emerging role in precision oncology.

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J Hepatol
Reversing the global burden of hepatocellular carcinoma.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
Calendar of Courses, Symposiums and Conferences.

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Calendar of Courses, Symposiums and Conferences.

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Extensive Pneumatosis due to Colonic Perforation.

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Hypertriglyceridemia-Associated Acute Pancreatitis.

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Letter to the Editor.

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Oesophageal band ligation successfully controlled sentinel bleeding from an Aorto-Oesophageal Fistula.

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Response to Chinitz and Menon.

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Clin Gastroenterol Hepatol
Building and Sustaining Inflammatory Bowel Disease (IBD) Specialty Care in the Community: Insights and Solutions from the AGA IBD Community Care Initiative.

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Comparative Effectiveness and Safety of Upadacitinib Versus Risankizumab for Ulcerative Colitis.

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Dynamic magnetic resonance imaging evaluation of the impact of endoscopic sleeve gastroplasty on gastric structure and function.

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Intraductal papillary neoplasm of the bile duct with associated invasive carcinoma diagnosed by peroral cholangioscopy with NBI.

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LiverPRO reduces false positives and screening costs compared with Fibrosis-4 Index in steatotic liver disease.

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Multilocus heterotopic gastric mucosa mimicking Crohn's disease.

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Periampullary Subepithelial Pseudotumor in Acute Cholangitis.

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Endoscopy
"Snow globe sign" in malignant ascites and pleural effusions: a helpful sonographic finding on endoscopic ultrasound.

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A bubble-free strategy for saline-immersion endoscopic submucosal dissection: optimized electrosurgical settings and continuous low-pressure saline perfusion.

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A case involving a submucosal bulge in the duodenal bulb was ultimately confirmed to be a residual gallbladder.

Pubmed   Journal   ReadQx   PMC

A novel 6 Fr inside biliary stent system for perihilar biliary drainage.

Pubmed   Journal   ReadQx   PMC

A novel endoscopic ultrasound system assisted by artificial intelligence for the recognition of pancreatic parenchyma and the detection of solid/cystic lesions.

Pubmed   Journal   ReadQx   PMC

A novel recanalization technique using inverted guidewire puncture under cholangioscopy for complete biliary stricture after liver transplantation.

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A triple-guidewire technique to stabilize the endoscope during endoscopic ultrasonography-guided pancreatic drainage following pancreaticoduodenectomy.

Pubmed   Journal   ReadQx   PMC

Antegrade bile duct stone removal with double guidewire deployment using a novel double-lumen dilator.

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Arterial bleeding during endoscopic ultrasound-guided pancreatic pseudocyst drainage using a novel ultrasound processor.

Pubmed   Journal   ReadQx   PMC

Cholangioscopy-guided retrieval of a migrated stent using a novel thin cholangioscope in a patient with Roux-en-Y gastrectomy.

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Combined gastric mucosal ablation of the fundus using a new hybrid device with endoscopic sleeve gastroplasty for obesity.

Pubmed   Journal   ReadQx   PMC

Complete resection of a duodenal submucosal tumor using clip-and-snare assisted endoscopic submucosal resection: a case report.

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Diagnosis of gallbladder villous tubular adenoma with high-grade intraepithelial neoplasia via peroral endoscopic choledochoscopy: a rare case of an elderly patient.

Pubmed   Journal   ReadQx   PMC

Double-balloon endoscopy-assisted bile duct biopsy with a long, tapered delivery system.

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Endoscopic closure of a gastrocutaneous fistula reopening 18 years after gastrostomy removal using argon plasma coagulation and endoscopic hand suturing.

Pubmed   Journal   ReadQx   PMC

Endoscopic intermuscular dissection, knife-assisted full-thickness resection and defect closure for early rectal cancer.

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Endoscopic removal of esophageal bezoars using a condom as a novel retrieval device.

Pubmed   Journal   ReadQx   PMC

Endoscopic rescue after lumen-apposing metal stent deployment failure during endoscopic ultrasound-guided drainage of a giant pancreatic pseudocyst.

Pubmed   Journal   ReadQx   PMC

Endoscopic submucosal dissection including the papilla for a duodenal adenoma using a high-pressure injection knife.

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Endoscopic submucosal dissection with a traction-guided rendezvous approach for sigmoid colon cancer in the distal limb of a double-barrel colostomy.

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Endoscopic ultrasonography-guided B3 branch drainage/anastomosis as hepaticoduodenostomy in atrophic left hepatic lobe case.

Pubmed   Journal   ReadQx   PMC

Endoscopic ultrasound-guided drainage for a delayed splenic abscess caused by electrocoagulation syndrome after endoscopic resection of small gastric submucosal tumor.

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Endoscopic ultrasound-guided dual-route recanalization of isolated hepatic ducts following complete hilar disconnection.

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Endoscopic ultrasound-guided perforator-targeted embolization for gastric variceal bleeding due to left-sided portal hypertension.

Pubmed   Journal   ReadQx   PMC

Evaluating the value and risks of endoscopic full-thickness resection for giant duodenal hamartomas.

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Fluoroscopy-guided, sheath-assisted biopsy for indeterminate intraductal biliary masses.

Pubmed   Journal   ReadQx   PMC

Gel immersion electrohydraulic lithotripsy for gallbladder stones through a lumen-apposing metal stent.

Pubmed   Journal   ReadQx   PMC

Novel application of metal-clip traction-assisted endoscopic intermuscular dissection for a rare calcifying fibrous tumor.

Pubmed   Journal   ReadQx   PMC

Novel therapeutic ultrathin endoscope facilitates endoscopic intermuscular dissection for gastrointestinal stromal tumor adjacent to the anus.

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Peroral cholangiopancreatoscopy-guided diagnosis and treatment of an intramural bile duct stone complicated with immunoglobulin G4-related cholangitis: a case report with video.

Pubmed   Journal   ReadQx   PMC

Peroral endoscopic tumor resection of a large esophageal leiomyoma using refined traction and extraction techniques.

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Preventing distal stent deflection using a sheath-assisted technique for malignant hilar biliary obstruction.

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Short-type single-balloon enteroscope-assisted endoscopic retrograde cholangiopancreatography for complete occlusion of the biliary-enteric anastomosis.

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Side-by-side placement and removability of a novel multi-hole self-expandable metallic stent for malignant hilar biliary obstruction.

Pubmed   Journal   ReadQx   PMC

Side-by-side plastic stent insertion for refractory post-endoscopic sphincterotomy bleeding after covered metal stent placement.

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Traction-band clip-assisted biliary cannulation for a papilla located in the horizontal limb after total gastrectomy.

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Trans-fistulous pancreatoscopy-guided pancreatic duct stone extraction after endoscopic ultrasound-guided pancreaticogastrostomy in post-Whipple patient.

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Tubeless percutaneous transhepatic one-step biliary fistulation combined with choledochoscopic lithotripsy for hepatolithiasis: a case report.

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Two-layer closure method using anchor pronged clips for endoscopic full-thickness resection.

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Use of a Zenker's diverticulum overtube for the safe extraction of an unusual gastric foreign body.

Pubmed   Journal   ReadQx   PMC

Use of a hemostatic matrix for control of bleeding during flexible endoscopic septotomy for Zenker's diverticulum.

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Gastroenterology
"The cure better not worse than the illness" - lessons from ethosuximide in irritable bowel syndrome.

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A Pelvic Cyst in a Patient with Acute Right Upper Quadrant Pain.

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A Rare and Reversible Cause of Gastric Wall Thickening and Severe Anemia.

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Adolescent Risk Factors for the Presence and Persistence of Irritable Bowel Syndrome in Young Adulthood-Findings From a Prospective Birth Cohort.

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FORECASTING THE INCIDENCE AND PREVALENCE OF INFLAMMATORY BOWEL DISEASE ACROSS NINE EPIDEMIOLOGIC STAGE 3 NATIONS.

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H Pylori Eradication in Healthy Adults Not Strongly Associated with Improved Mortality: A Fragility Index Analysis.

Pubmed   Journal   ReadQx 

Improving efficacy without increasing side effects? Exploring the impact of a novel GLP-1-glucagon dual receptor agonist upon metabolic dysfunction-associated steatohepatitis.

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Incidence of Rectal Cancer in Patients with Isolated Ulcerative Proctitis - A Population-Based Cohort Study.

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Involvement of Eosinophil-Driven Intestinal Immune Activation in Different Irritable Bowel Syndrome Subtypes and in the Response to a FODMAP Lowering Diet: A Post Hoc Analysis of the Randomized Controlled DOMINO Trial.

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Long-Term, Prospective Assessment of Cancer Risk in APC c.3920T>A (I1307K) Carriers: Evidence From a Cohort of Over 21,000 Healthy Individuals.

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Microbes and macrophages: how they interact to promote ulcerative colitis.

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TET3 is a Common Epigenetic Immunomodulator of Pathogenic Macrophages.

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Time-Restricted Feeding Reduces Body Mass Index, Visceral Adiposity, Systemic Inflammation, and Clinical Disease Activity in Adults With Crohn's Disease: A Randomized Controlled Study.

Pubmed   Journal   ReadQx 

Unusual Crohn's-like Enteritis in a Female Pediatric Patient.

Pubmed   Journal   ReadQx 

Gastrointest Endosc
Cholesterosis Beyond the Gallbladder: A Rare Case of Common Bile Duct Involvement Associated with Pancreaticobiliary Union.

Pubmed   Journal   ReadQx 

Radiofrequency ablation for a malignant biliary stricture by unresectable small-cell neuroendocrine carcinoma of the common bile duct (with video).

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Recurrent Pyloric Stenosis in a Roux-en-Y Gastric Bypass Patient Treated with EUS-Guided Gastrojejunostomy.

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Top tips for the endoscopic management of incompletely resected polyps (with videos).

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When CT Falls Short: Role of EUS and Peroral Pancreatoscopy in Identifying Main Duct Intraductal Papillary Mucinous Neoplasm in Patients with Asymptomatic Elevated CA19-9.

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Gut
Catch me if you can! Is there protection from HCV (re)infection?

Pubmed   Journal   ReadQx 

Exploiting a purine imbalance to target <i>KRAS</i> mutant pancreatic adenocarcinomas.

Pubmed   Journal   ReadQx 

From IPMN to invasive pancreatic cancer: new spatial insights.

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Hydroxylation matters! Microbial bile acid metabolism and colorectal cancer.

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Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection.

Pubmed   Journal   ReadQx 

Hepatology
Letter to the editor: Hepatocyte-derived extracellular vesicles promote endothelial pyroptosis in chronic liver disease: Undefined role of miR-153-3p.

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Reply: Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease.

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Shedding new light on the chicken-and-egg dilemma of hepatitis delta virus (HDV) replication initiation.

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Thawing "cold" tumors: The NRF2-COX2-PGE2 axis as a pathway to precision immunotherapy in HCC.

Pubmed   Journal   ReadQx 

Unravelling the immunogenetic architecture of cholangiocarcinoma.

Pubmed   Journal   ReadQx 

J Hepatol
Hepatic zonation as the gatekeeper of β-catenin oncogenic transformation.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Editorial: Beyond Viral Eradication-Cardiometabolic Risk and Cardiovascular Outcomes After SVR in Chronic Hepatitis C. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter on: 'Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS'.

Pubmed   Journal   ReadQx 

Letter on: 'Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS'. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: A Patient Centric Approach to Tapering Steroids in Steroid Responsive Moderate to Severely Active Ulcerative Colitis.

Pubmed   Journal   ReadQx 

Letter: A Patient Centric Approach to Tapering Steroids in Steroid Responsive Moderate to Severely Active Ulcerative Colitis. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: Rifaximin Versus Low FODMAP Diet in IBS: What the Primary Endpoint Does Not Tell Us.

Pubmed   Journal   ReadQx 

Letter: Rifaximin Versus Low FODMAP Diet in IBS: What the Primary Endpoint Does Not Tell Us. Authors' Reply.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol
Cost-effectiveness of Novel Colorectal Neoplasia Screening Tests.

Pubmed   Journal   ReadQx 

Reply: Cost-effectiveness of Novel Noninvasive Screening Tests for Colorectal Neoplasia.

Pubmed   Journal   ReadQx 

Gastroenterology
Beyond Curability: Age and Surgical Risk in Individualized Treatment of T1 Colorectal Cancer.

Pubmed   Journal   ReadQx 

Caution in Generalizing the Safety of Isolated Deep Submucosal Invasion in T1 Colorectal Cancer.

Pubmed   Journal   ReadQx 

Comments on "Total Pancreatectomy With Islet Autotransplantation for Chronic Pancreatitis".

Pubmed   Journal   ReadQx 

Defying GRAVITI - Reporting safety data in treat-through studies with rescue mechanisms.

Pubmed   Journal   ReadQx 

Diet and Chronic Constipation: Key Considerations of Subtype Specificity, Synergistic Effects, and Temporal Dynamics.

Pubmed   Journal   ReadQx 

Shared Decision Making in the Management of High-Risk T1 Colorectal Cancer.

Pubmed   Journal   ReadQx 

Gastrointest Endosc
Enhancing risk-based Barrett's esophagus screening through streamlined referral pathways.

Pubmed   Journal   ReadQx 

Is it time to abandon night-before laxative bowel preparation for small-bowel capsule endoscopy?

Pubmed   Journal   ReadQx 

Open Zenker without mucosal closure: novel to gastroenterology but not to otorhinolaryngology.

Pubmed   Journal   ReadQx 

The reliability of the endoscopic submucosal dissection versus transanal minimally invasive surgery recovery comparison: examining indication bias, baseline imbalance, and limited statistical power.

Pubmed   Journal   ReadQx 

Gut
Beyond gastrointestinal symptom burden: exploring the impact of previous cholecystectomy on ultrasound-based hepatocellular carcinoma surveillance in patients with liver cirrhosis.

Pubmed   Journal   ReadQx 

Challenges in defining MASLD in lean individuals: the impact of the Fatty Liver Index on phenotypic characterisation.

Pubmed   Journal   ReadQx 

Clarifying the decision rules and implementation boundaries for risk-based HCC surveillance in MASLD.

Pubmed   Journal   ReadQx 

Combined response to letters to the editors.

Pubmed   Journal   ReadQx 

Defining preclinical stages of Crohn's disease by faecal calprotectin and other risk factors: response to letter.

Pubmed   Journal   ReadQx 

Gastric cancer attributable to Helicobacter pylori in 2040.

Pubmed   Journal   ReadQx 

Gut health is associated with clonal haematopoiesis in older adults with and without HIV: the ARCHIVE longitudinal cohort study.

Pubmed   Journal   ReadQx 

Negative trial, positive lessons: refining endpoints and eligibility in RAP/CP prevention studies.

Pubmed   Journal   ReadQx 

Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives.

Pubmed   Journal   ReadQx 

Real-world treatment patterns in microscopic colitis: a nationwide study from Sweden.

Pubmed   Journal   ReadQx 

Repositioning dual GLP-1/GIP receptor agonists for the treatment of colitis and colitis-associated tumourigenesis.

Pubmed   Journal   ReadQx 

SIMBA trial: reasons for failure despite sound principle.

Pubmed   Journal   ReadQx 

J Hepatol
Author response: Language barriers for adoption of artificial intelligence in hepatology.

Pubmed   Journal   ReadQx 

Obesity definitions reshape cardiovascular risk within MASLD.

Pubmed   Journal   ReadQx 

Progress and Remaining Barriers in Liver Xenotransplantation.

Pubmed   Journal   ReadQx 

The 2025 BCLC Staging System: Should Potential Liver Transplantation Be Prioritized?

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